@article{oai:kutarr.kochi-tech.ac.jp:00000119, author = {OHAMA, Takeshi and INAGAKI, Yuji and BESSHO, Yoshitaka and OSAWA, Syozo}, issue = {2}, journal = {Proceedings of the Japan Academy. Ser. B, Physical and biological sciences.}, month = {}, note = {In 1985, we reported that a bacterium, Mycoplasma capricolum, used a deviant genetic code, namely UGA, a “universal” stop codon, was read as tryptophan. This finding, together with the deviant nuclear genetic codes in not a few organisms and a number of mitochondria, shows that the genetic code is not universal, and is in a state of evolution. To account for the changes in codon meanings, we proposed the codon capture theory stating that all the code changes are non-disruptive without accompanied changes of amino acid sequences of proteins. Supporting evidence for the theory is presented in this review. A possible evolutionary process from the ancient to the present-day genetic code is also discussed.}, pages = {58--74}, title = {Evolving genetic code}, volume = {84}, year = {2008} }