@article{oai:kutarr.kochi-tech.ac.jp:00000129,
 author = {Sakai, Kenichi and Sakurai, Rumiko and Yuzawa, Atsushi and Kobayashi, Yuka and Saigo, Kazuhiko},
 issue = {12},
 journal = {Tetrahedron: Asymmetry},
 month = {Jun},
 note = {The resolution of racemic 3-(methylamino)-1-(2-thienyl)propan-1-ol (3), a new key intermediate for duloxetine (1), was studied.  The conditions were optimized for an industrial-scale resolution of 3 by using (S)-mandelic acid (4) as a resolving agent and 2-butanol containing two equimolar amounts of water as a solvent.  The (S)-3･(S)-4･H2O diastereomeric salt was crystallized to give pure (S)-3 with >99.9% ee after liberation of the amine.  Absolute configuration of liberated (-)-3 was determined as (S)-form by X-ray crystallography.},
 pages = {1631--1636},
 title = {Resolution of 3-(methylamino)-1-(2-thienyl)propan-1-ol, a new key intermediate for duloxetine, with (S)-mandelic acid},
 volume = {14},
 year = {2003}
}