{"created":"2023-05-15T12:35:12.558172+00:00","id":129,"links":{},"metadata":{"_buckets":{"deposit":"a58d3902-dba5-433b-b3d9-bc5a224dc3bf"},"_deposit":{"created_by":2,"id":"129","owners":[2],"pid":{"revision_id":0,"type":"depid","value":"129"},"status":"published"},"_oai":{"id":"oai:kutarr.kochi-tech.ac.jp:00000129","sets":["5"]},"author_link":["462","464","463","461","460"],"item_2_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2003-06-20","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"12","bibliographicPageEnd":"1636","bibliographicPageStart":"1631","bibliographicVolumeNumber":"14","bibliographic_titles":[{"bibliographic_title":"Tetrahedron: Asymmetry"}]}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The resolution of racemic 3-(methylamino)-1-(2-thienyl)propan-1-ol (3), a new key intermediate for duloxetine (1), was studied.  The conditions were optimized for an industrial-scale resolution of 3 by using (S)-mandelic acid (4) as a resolving agent and 2-butanol containing two equimolar amounts of water as a solvent.  The (S)-3･(S)-4･H2O diastereomeric salt was crystallized to give pure (S)-3 with >99.9% ee after liberation of the amine.  Absolute configuration of liberated (-)-3 was determined as (S)-form by X-ray crystallography.","subitem_description_type":"Abstract"}]},"item_2_publisher_35":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Elsevier"}]},"item_2_relation_13":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1016/S0957-4166(03)00315-X","subitem_relation_type_select":"DOI"}}]},"item_2_relation_44":{"attribute_name":"関係URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"http://www.sciencedirect.com/science/journal/09574166"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://www.sciencedirect.com/science/journal/09574166","subitem_relation_type_select":"URI"}}]},"item_2_rights_14":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2003 Elsevier Science Ltd. All rights reserved."}]},"item_2_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA1074621X","subitem_source_identifier_type":"NCID"}]},"item_2_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0957-4166","subitem_source_identifier_type":"ISSN"}]},"item_2_version_type_18":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Sakai, Kenichi"}],"nameIdentifiers":[{"nameIdentifier":"460","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Sakurai, Rumiko"}],"nameIdentifiers":[{"nameIdentifier":"461","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yuzawa, Atsushi"}],"nameIdentifiers":[{"nameIdentifier":"462","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kobayashi, Yuka"}],"nameIdentifiers":[{"nameIdentifier":"463","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Saigo, Kazuhiko"}],"nameIdentifiers":[{"nameIdentifier":"464","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-02-13"}],"displaytype":"detail","filename":"ttrasy_14_1631.pdf","filesize":[{"value":"146.3 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"ttrasy_14_1631.pdf","url":"https://kutarr.kochi-tech.ac.jp/record/129/files/ttrasy_14_1631.pdf"},"version_id":"ce348489-0f39-4d32-bc2c-dfe5cab982cc"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Resolution of 3-(methylamino)-1-(2-thienyl)propan-1-ol, a new key intermediate for duloxetine, with (S)-mandelic acid","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Resolution of 3-(methylamino)-1-(2-thienyl)propan-1-ol, a new key intermediate for duloxetine, with (S)-mandelic acid"}]},"item_type_id":"2","owner":"2","path":["5"],"pubdate":{"attribute_name":"公開日","attribute_value":"2011-08-30"},"publish_date":"2011-08-30","publish_status":"0","recid":"129","relation_version_is_last":true,"title":["Resolution of 3-(methylamino)-1-(2-thienyl)propan-1-ol, a new key intermediate for duloxetine, with (S)-mandelic acid"],"weko_creator_id":"2","weko_shared_id":-1},"updated":"2023-05-15T13:43:56.806041+00:00"}