@article{oai:kutarr.kochi-tech.ac.jp:00000190, author = {Suzuki, Tsutomu and Suzuki, Takeo and Wada, Takeshi and Saigo, Kazuhiko and Watanabe, Kimitsuna}, issue = {1}, journal = {Nucleic Acids Research Supplement}, month = {Jun}, note = {Two novel modified uridines were identified from mammalian mitochondrial (mt) tRNAs. Mass spectrometric analysis revealed that they are modified uridines possessing a sulfonic acid group derived from taurine; 5-taurinomethyluridine from mt tRNAs for Trp and Leu(UUR), and 5-taurinomethyl-2-thiouridine from mt tRNAs for Lys, Gin and Glu. We have found lack of modification of these taurine-containing uridines in mutant mt tRNAs for Leu(UUR) and Lys from pathogenic cells of mitochondrial encephalomyopathies, MELAS and MERRF, respectively.}, pages = {257--258}, title = {Novel taurine-containing uridine derivatives and mitochondrial human diseases}, volume = {1}, year = {1905} }