@article{oai:kutarr.kochi-tech.ac.jp:00000194, author = {Oka, Natsuhisa and Wada, Takeshi and Saigo, Kazuhiko}, issue = {1}, journal = {Nucleic Acids Research Supplement}, month = {Jun}, note = {Diastereopure nucleoside 3′-cyclic phosphoramidites were synthesized stereoselectively from enantiopure 1,2-amino alcohols. In the presence of a novel activator, these phosphoramidites underwent the condensation with 3′-O-tert-butyldimethylsilylthymidine to give the corresponding phosphite intermediates. Upon sulfurization, followed by deprotection, dithymidine phosphorothioate was obtained in good yield with good to excellent diastereoselectivity.}, pages = {13--14}, title = {Stereoselective synthesis of dinucleoside phosphorothioate using enantiopure 1,2-amino alcohols as chiral auxiliaries}, volume = {1}, year = {1905} }