@article{oai:kutarr.kochi-tech.ac.jp:00000196, author = {Wada, Takeshi and Tsuneyama, Toshikazu and Saigo, Kazuhiko}, issue = {1}, journal = {Nucleic Acids Research Supplement}, month = {Jun}, note = {This paper describes the synthesis of a new type of nucleic acid analog derived from L-serine with ester linkages. The monomer unit bearing thymine base was synthesized from L-serine ethyl ester by a three-step reaction in good yield without racemization. 3-Nitro-l,2,4-triazol-l-yl-tris(pyrrolidin-l-yl)phosphonium hexafluorophosphate (PyNTP) was found to be highly effective for the rapid ester bond formation without racemization. 2-Phenyl-2-(trimethylsilyl)ethyl group was successfully employed as a carboxyl protecting group in solution-phase synthesis.}, pages = {187--188}, title = {Synthesis of a new type of artificial nucleic acid derived from optically active serine}, volume = {1}, year = {1905} }