@article{oai:kutarr.kochi-tech.ac.jp:00000236,
 author = {Nishiwaki, Nagatoshi and Kobiro, Kazuya and Hirao, Shotaro and Sawayama, Jun and Saigo, Kazuhiko and Ise, Yumiko and Nishizawa, Maho and Ariga, Masahiro},
 issue = {10},
 journal = {Organic & Biomolecular Chemistry},
 month = {},
 note = {A new protocol for synthesizing different functionalized isoxazoles is provided. Carbamoylnitrile oxide generated from nitroisoxazolone underwent inverse electron-demand 1,3-dipolar cycloaddition with 1,3-dicarbonyl compounds in the presence of magnesium acetate that formed magnesium enolatein situ. Although electron-deficient trifluoroacetoacetate did not undergo this cycloaddition under the same conditions, conversion to sodium enolate furnish the corresponding bis-functionalized trifluoromethylisoxazole. The DFT calculations using B3LYP 6-31G+(d,p) also supported the aforementioned reactivity.},
 pages = {1987--1991},
 title = {One-step synthesis of differently bis-functionalized isoxazoles by cycloaddition of carbamoylnitrile oxide with β-keto esters},
 volume = {10},
 year = {2012}
}