| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2016-03-25 |
| タイトル |
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タイトル |
Synthesis of Vicinally Functionalized 1,4-Dihydropyridines and Diazabicycles via a Pseudo-Intramolecular Process |
| 言語 |
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言語 |
eng |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 著者 |
Nishiwaki, Nagatoshi
Hirao, Shotaro
Sawayama, Jun
Asahara, Haruyasu
Sugimoto, Ryuichi
Kobiro, Kazuya
Saigo, Kazuhiko
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| 抄録 |
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内容記述タイプ |
Abstract |
|
内容記述 |
An α-nitro-δ-keto nitrile readily forms the corresponding ammonium salt immediately upon treatment with an amine. When the amine liberated under equilibrium, the nucleophilic amine and the electrophilic keto nitrile come close to each other to afford so-called an intimate pair. The spatial proximity realized an efficient reaction to give a 2-amino-3-nitro-1,4-dihydropyridine; the reaction proceeded like an intramolecular reaction although it is actually an intermolecular reaction, namely the pseudo-intramolecular reaction. The bifunctionality of the keto nitrile also enabled the pseudo-intramolecular imination followed by tandem cyclization leading to diazabicyclic frameworks. |
| 書誌情報 |
Tetrahedron
巻 70,
号 2,
p. 402-408,
発行日 2014
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| DOI |
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関連タイプ |
isVersionOf |
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識別子タイプ |
DOI |
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関連識別子 |
10.1016/j.tet.2013.11.044 |
| 著者版フラグ |
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出版タイプ |
AM |
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出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
| 出版者 |
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出版者 |
Elsevier Ltd. |
27-24.pdf (372.5 kB)
