| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2013-03-29 |
| タイトル |
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|
タイトル |
Novel taurine-containing uridine derivatives and mitochondrial human diseases |
| 言語 |
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|
言語 |
eng |
| 資源タイプ |
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|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 著者 |
Suzuki, Tsutomu
Suzuki, Takeo
Wada, Takeshi
Saigo, Kazuhiko
Watanabe, Kimitsuna
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| 抄録 |
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内容記述タイプ |
Abstract |
|
内容記述 |
Two novel modified uridines were identified from mammalian mitochondrial (mt) tRNAs. Mass spectrometric analysis revealed that they are modified uridines possessing a sulfonic acid group derived from taurine; 5-taurinomethyluridine from mt tRNAs for Trp and Leu(UUR), and 5-taurinomethyl-2-thiouridine from mt tRNAs for Lys, Gin and Glu. We have found lack of modification of these taurine-containing uridines in mutant mt tRNAs for Leu(UUR) and Lys from pathogenic cells of mitochondrial encephalomyopathies, MELAS and MERRF, respectively. |
| 書誌情報 |
Nucleic Acids Research Supplement
巻 1,
号 1,
p. 257-258,
発行日 1905-06-23
|
| ISSN |
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収録物識別子タイプ |
ISSN |
|
収録物識別子 |
0261-3166 |
| DOI |
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関連タイプ |
isIdenticalTo |
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|
識別子タイプ |
DOI |
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関連識別子 |
10.1093/nass/1.1.257 |
| 権利（URI） |
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|
権利情報 |
http://nass.oxfordjournals.org/content/1/1/257 | http://nass.oxfordjournals.org/content/1/1/257 |
| 著者版フラグ |
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|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 出版者 |
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出版者 |
Oxford University Press |
NARS_1_1_257.pdf (151.8 kB)
