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Novel taurine-containing uridine derivatives and mitochondrial human diseases
http://hdl.handle.net/10173/961
http://hdl.handle.net/10173/961c14ca983-ccf6-4440-8bcb-3abee7ccdaec
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
NARS_1_1_257.pdf (151.8 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2013-03-29 | |||||
| タイトル | ||||||
| タイトル | Novel taurine-containing uridine derivatives and mitochondrial human diseases | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
Suzuki, Tsutomu
× Suzuki, Tsutomu× Suzuki, Takeo× Wada, Takeshi× Saigo, Kazuhiko× Watanabe, Kimitsuna |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Two novel modified uridines were identified from mammalian mitochondrial (mt) tRNAs. Mass spectrometric analysis revealed that they are modified uridines possessing a sulfonic acid group derived from taurine; 5-taurinomethyluridine from mt tRNAs for Trp and Leu(UUR), and 5-taurinomethyl-2-thiouridine from mt tRNAs for Lys, Gin and Glu. We have found lack of modification of these taurine-containing uridines in mutant mt tRNAs for Leu(UUR) and Lys from pathogenic cells of mitochondrial encephalomyopathies, MELAS and MERRF, respectively. | |||||
| 書誌情報 |
Nucleic Acids Research Supplement 巻 1, 号 1, p. 257-258, 発行日 1905-06-23 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0261-3166 | |||||
| DOI | ||||||
| 関連タイプ | isIdenticalTo | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1093/nass/1.1.257 | |||||
| 権利（URI） | ||||||
| 権利情報 | http://nass.oxfordjournals.org/content/1/1/257 | http://nass.oxfordjournals.org/content/1/1/257 | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| 出版者 | ||||||
| 出版者 | Oxford University Press | |||||
