| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2013-03-29 |
| タイトル |
|
|
タイトル |
Stereoselective synthesis of dinucleoside phosphorothioate using enantiopure 1,2-amino alcohols as chiral auxiliaries |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 著者 |
Oka, Natsuhisa
Wada, Takeshi
Saigo, Kazuhiko
|
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Diastereopure nucleoside 3′-cyclic phosphoramidites were synthesized stereoselectively from enantiopure 1,2-amino alcohols. In the presence of a novel activator, these phosphoramidites underwent the condensation with 3′-O-tert-butyldimethylsilylthymidine to give the corresponding phosphite intermediates. Upon sulfurization, followed by deprotection, dithymidine phosphorothioate was obtained in good yield with good to excellent diastereoselectivity. |
| 書誌情報 |
Nucleic Acids Research Supplement
巻 1,
号 1,
p. 13-14,
発行日 1905-06-23
|
| ISSN |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
0261-3166 |
| DOI |
|
|
関連タイプ |
isIdenticalTo |
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
10.1093/nass/1.1.13 |
| 権利（URI） |
|
|
権利情報 |
http://nass.oxfordjournals.org/content/1/1/13 | http://nass.oxfordjournals.org/content/1/1/13 |
| 著者版フラグ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 出版者 |
|
|
出版者 |
Oxford University Press |
NARS_1_1_13.pdf (141.2 kB)
