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  1. 学術雑誌論文

Stereoselective synthesis of dinucleoside phosphorothioate using enantiopure 1,2-amino alcohols as chiral auxiliaries

http://hdl.handle.net/10173/965
http://hdl.handle.net/10173/965
46556f8b-1d04-4cbb-98a8-5ee30110e4b6
名前 / ファイル ライセンス アクション
NARS_1_1_13.pdf NARS_1_1_13.pdf (141.2 kB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2013-03-29
タイトル
タイトル Stereoselective synthesis of dinucleoside phosphorothioate using enantiopure 1,2-amino alcohols as chiral auxiliaries
言語
言語 eng
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
著者 Oka, Natsuhisa

× Oka, Natsuhisa

WEKO 767

Oka, Natsuhisa

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Wada, Takeshi

× Wada, Takeshi

WEKO 768

Wada, Takeshi

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Saigo, Kazuhiko

× Saigo, Kazuhiko

WEKO 769

Saigo, Kazuhiko

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抄録
内容記述タイプ Abstract
内容記述 Diastereopure nucleoside 3′-cyclic phosphoramidites were synthesized stereoselectively from enantiopure 1,2-amino alcohols. In the presence of a novel activator, these phosphoramidites underwent the condensation with 3′-O-tert-butyldimethylsilylthymidine to give the corresponding phosphite intermediates. Upon sulfurization, followed by deprotection, dithymidine phosphorothioate was obtained in good yield with good to excellent diastereoselectivity.
書誌情報 Nucleic Acids Research Supplement

巻 1, 号 1, p. 13-14, 発行日 1905-06-23
ISSN
収録物識別子タイプ ISSN
収録物識別子 0261-3166
DOI
関連タイプ isIdenticalTo
識別子タイプ DOI
関連識別子 10.1093/nass/1.1.13
権利(URI)
権利情報 http://nass.oxfordjournals.org/content/1/1/13 | http://nass.oxfordjournals.org/content/1/1/13
著者版フラグ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
出版者
出版者 Oxford University Press
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