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One-step synthesis of differently bis-functionalized isoxazoles by cycloaddition of carbamoylnitrile oxide with β-keto esters
http://hdl.handle.net/10173/1358
http://hdl.handle.net/10173/1358cda1fc33-18cf-4f47-a3b8-532a8c5ffc34
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
27-21.pdf (201.0 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2016-03-25 | |||||
| タイトル | ||||||
| タイトル | One-step synthesis of differently bis-functionalized isoxazoles by cycloaddition of carbamoylnitrile oxide with β-keto esters | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
Nishiwaki, Nagatoshi
× Nishiwaki, Nagatoshi× Kobiro, Kazuya× Hirao, Shotaro× Sawayama, Jun× Saigo, Kazuhiko× Ise, Yumiko× Nishizawa, Maho× Ariga, Masahiro |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | A new protocol for synthesizing different functionalized isoxazoles is provided. Carbamoylnitrile oxide generated from nitroisoxazolone underwent inverse electron-demand 1,3-dipolar cycloaddition with 1,3-dicarbonyl compounds in the presence of magnesium acetate that formed magnesium enolatein situ. Although electron-deficient trifluoroacetoacetate did not undergo this cycloaddition under the same conditions, conversion to sodium enolate furnish the corresponding bis-functionalized trifluoromethylisoxazole. The DFT calculations using B3LYP 6-31G+(d,p) also supported the aforementioned reactivity. | |||||
| 書誌情報 |
Organic & Biomolecular Chemistry 巻 10, 号 10, p. 1987-1991, 発行日 2012 |
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| DOI | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1039/C2OB06925C | |||||
| 権利（URI） | ||||||
| 権利情報 | http://pubs.rsc.org/en/content/articlelanding/2012/ob/c2ob06925c#!divAbstract | http://pubs.rsc.org/en/content/articlelanding/2012/ob/c2ob06925c#!divAbstract | |||||
| 著者版フラグ | ||||||
| 出版タイプ | AM | |||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
| 出版者 | ||||||
| 出版者 | Royal Society of Chemistry | |||||
