| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2016-03-25 |
| タイトル |
|
|
タイトル |
One-step synthesis of differently bis-functionalized isoxazoles by cycloaddition of carbamoylnitrile oxide with β-keto esters |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 著者 |
Nishiwaki, Nagatoshi
Kobiro, Kazuya
Hirao, Shotaro
Sawayama, Jun
Saigo, Kazuhiko
Ise, Yumiko
Nishizawa, Maho
Ariga, Masahiro
|
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
A new protocol for synthesizing different functionalized isoxazoles is provided. Carbamoylnitrile oxide generated from nitroisoxazolone underwent inverse electron-demand 1,3-dipolar cycloaddition with 1,3-dicarbonyl compounds in the presence of magnesium acetate that formed magnesium enolatein situ. Although electron-deficient trifluoroacetoacetate did not undergo this cycloaddition under the same conditions, conversion to sodium enolate furnish the corresponding bis-functionalized trifluoromethylisoxazole. The DFT calculations using B3LYP 6-31G+(d,p) also supported the aforementioned reactivity. |
| 書誌情報 |
Organic & Biomolecular Chemistry
巻 10,
号 10,
p. 1987-1991,
発行日 2012
|
| DOI |
|
|
関連タイプ |
isVersionOf |
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
10.1039/C2OB06925C |
| 権利（URI） |
|
|
権利情報 |
http://pubs.rsc.org/en/content/articlelanding/2012/ob/c2ob06925c#!divAbstract | http://pubs.rsc.org/en/content/articlelanding/2012/ob/c2ob06925c#!divAbstract |
| 著者版フラグ |
|
|
出版タイプ |
AM |
|
出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
| 出版者 |
|
|
出版者 |
Royal Society of Chemistry |
27-21.pdf (201.0 kB)
